2004•Chinese Journal of Hospital PharmacyRequires access
Inhibitory effect of extracts of the core of lithion the expression of HBsAg and HBeAg in the HepG 2.2.15 cells
Qing Xu
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Abstract
OBJECTIVE To investigate the active parts of the extracts of the core of Litchi and their effect on the HBV. METHODS HepG 2.215 cell culture system was used for study of the expressions of HBsAg and HBeAg with A、B、C、D、E、F of the extract components from the core of litchi. RESULTS All extracts A、B、C、D、E 、F (200,100 mg·L -1) of the core of litchi. Were shown to inhibit the expression of HBsAg and HBeAg in HepG 2.2.15 cells, among which the extract E was the most effective, at 200 mg·L -1 in the medium, HBsAg expression was inhibited by 50%, and HBeAg by 20% in the third day of the experiment, and in the 9 th day, the HBsAg was inhibited by 90.9%, the HBeAg by 84.3%(P 0.01, compared to the control group). CONCLUSION The extracts of the core of litchi are very effective in inhibition of HBV in vitro.