ScholarLens Back to search
2000•Zhonghua gan-dan waike zazhiRequires access

Expression and significance of P16 protein in hepatocellular carcinoma and tissues surrounding carcinoma

HU Zongze

Open publisher page 0 citations

Abstract

Objective To investigate the expression of carcinoma suppressor gene p16 in primary hepatocellular carcinoma (HCC) and its clinical significance. Methods Samples from 50 cases of HCC and 44 cases of liver tissue surrounding carcinoma were studied by immunohistochemical technique. Results The positive rate of p16 expression was 48% in carcinoma, 91% in tissue surrounding cancer. The expression of p16 was significantly correlated with degree of differentiation (P=0.014): the positive rate in Edmondson′s Ⅰ Ⅱ grade (59%) was higher than in Ⅲ Ⅳ grade (27.8%). Conclusions The deletion and mutation of p16 gene exist in HCC, and might be the early event of HCC. p16 Gene expression may play an important role in differentiation of HCC.

About this research paper

What this paper is about

Objective To investigate the expression of carcinoma suppressor gene p16 in primary hepatocellular carcinoma (HCC) and its clinical significance. Methods Samples from 50 cases of HCC and 44 cases of liver tissue surrounding carcinoma were studied by immunohistochemical technique. Results The positive rate of p16 expression was 48% in carcinoma, 91% in tissue surrounding cancer. The expression of p16 was significantly correlated with degree of differentiation (P=0.014): the positive rate in Edmondson′s Ⅰ Ⅱ grade (59%) was higher than in Ⅲ Ⅳ grade (27.8%). Conclusions The deletion and mutation of p16 gene exist in HCC, and might be the early event of HCC. p16 Gene expression may play an important role in differentiation of HCC.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Objective To investigate the expression of carcinoma suppressor gene p16 in primary hepatocellular carcinoma (HCC) and its clinical significance. Methods Samples from 50 cases of HCC and 44 cases of liver tissue surrounding carcinoma were studied by immunohistochemical technique. Results The positive rate of p16 expression was 48% in carcinoma, 91% in tissue surrounding cancer. The expression of p16 was significantly correlated with degree of differentiation (P=0.014): the positive rate in Edmondson′s Ⅰ Ⅱ grade (59%) was higher than in Ⅲ Ⅳ grade (27.8%). Conclusions The deletion and mutation of p16 gene exist in HCC, and might be the early event of HCC. p16 Gene expression may play an important role in differentiation of HCC.

Key concepts: Hepatocellular carcinoma, Immunohistochemistry, Carcinoma, Clinical significance, Cancer research, Gene, Liver cancer, Gene expression

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Expression and significance of P16 protein in hepatocellular carcinoma and tissues surrounding carcinoma — Research Paper | ScholarLens