ScholarLens Back to search
1998•Unpublished venueRequires access

Significance of P16 protein expression in hepatocellular carcinoma tissues

Wang Ying

Open publisher page 0 citations

Abstract

AIM To study the relation of P16 protein expression in hepatocellular carcinoma (HCC) with metastasis and prognosis. METHODS P16 protein expression was studied in 45 patients with HCC by using immunohistochemical LSAB method and compared with clinical materials. RESULTS P16 protein positive expression in the tumors and their neighboring regions was 40 0% and 84 4%, with a significant difference ( P 0 05). The positive expression of P16 protein was 20 0% in the carcinoma with metastasis and 60 5% without metastasis. P16 protein expression in highly, moderately and poorly differentiated HCC was 50 0%, 27 8% and 22 2%, with an obvious difference between patients with highly differentiated and poorly differentiated HCC ( P 0 05) , between groups with and without metastasis ( P 0 01) . CONCLUSION P16 protein expression is closely related to proliferation, malignant potential and prognosis of HCC.

About this research paper

What this paper is about

AIM To study the relation of P16 protein expression in hepatocellular carcinoma (HCC) with metastasis and prognosis. METHODS P16 protein expression was studied in 45 patients with HCC by using immunohistochemical LSAB method and compared with clinical materials. RESULTS P16 protein positive expression in the tumors and their neighboring regions was 40 0% and 84 4%, with a significant difference ( P 0 05). The positive expression of P16 protein was 20 0% in the carcinoma with metastasis and 60 5% without metastasis. P16 protein expression in highly, moderately and poorly differentiated HCC was 50 0%, 27 8% and 22 2%, with an obvious difference between patients with highly differentiated and poorly differentiated HCC ( P 0 05) , between groups with and without metastasis ( P 0 01) . CONCLUSION P16 protein expression is closely related to proliferation, malignant potential and prognosis of HCC.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

AIM To study the relation of P16 protein expression in hepatocellular carcinoma (HCC) with metastasis and prognosis. METHODS P16 protein expression was studied in 45 patients with HCC by using immunohistochemical LSAB method and compared with clinical materials. RESULTS P16 protein positive expression in the tumors and their neighboring regions was 40 0% and 84 4%, with a significant difference ( P 0 05). The positive expression of P16 protein was 20 0% in the carcinoma with metastasis and 60 5% without metastasis. P16 protein expression in highly, moderately and poorly differentiated HCC was 50 0%, 27 8% and 22 2%, with an obvious difference between patients with highly differentiated and poorly differentiated HCC ( P 0 05) , between groups with and without metastasis ( P 0 01) . CONCLUSION P16 protein expression is closely related to proliferation, malignant potential and prognosis of HCC.

Key concepts: Hepatocellular carcinoma, Immunohistochemistry, Metastasis, Clinical significance, Significant difference, Protein expression, Medicine, Cancer research

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Significance of P16 protein expression in hepatocellular carcinoma tissues — Research Paper | ScholarLens