2008•Applied Journal of General PracticeRequires access
Clinical Effect of Adefovir Dipivoxil for Chronic Hepatitis B
Yanfen Chai
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Abstract
Objective To investigate the affection of Adefovir dipivoxil on the serum fibrosis marks in patients with chronic hepatitis B.Methods 120 patients with chronic hepatitis B were randomly divided into treatment group and control group.The treatment group(n=60) was treated with Adefovir dipivoxil.The levels of serum hyaluronic acid(HA),laminin(LN),type Ⅲ procollagen(PcⅢ),type Ⅳ collagen(Ⅳc) of each group were detected before treatment and after 1 year of treatment.Results The level of serum HA,lN,pCⅢ and Ivc significantly decreased after the treatment of Adefovir dipivoxil(P0.01).The level of each indexes of the treatment groups was obviously different from that of the control group after the treatment(P0.01).Conclusions Adefovir dipivoxil could obviously decrease the serum hepatic fibrosis index in patients with chromic hepatitis B.