2009•Zhongguo xiao-yiRequires access

Observation on chronic hepatitis B patients treated with adefovir dipivoxil

Mei Hon

Abstract

Objective To investigate the changes of serum fibrosis marks of chronic hepatitis B patients treated with adefovir dipivoxil. Methods A total of 120 patients with chronic hepatitis B were randomly divided into a treatment group and a control group. The treatment group (60 patients) was treated with adefovir dipivoxil. The levels of serum byaluronic acid (HA),laminin (LN),type Ⅲ procollagen (PcⅢ) and laminin (IVc) of each group were detected before and after the treatment. Results The levels of serum HA,LN,PcⅢ and IVc significantly decreased after the treatment of adefovir dipivoxil,P0.01,and the levels of serum HA,LN,PcⅢ and IVc of the treatment group were obviously different from those of the control group after the treatment,P0.01. Conclusions Adefovir dipivoxil could obviously decrease the serum hepatic fibrosis indexes in the patients with chromic hepatitis B.

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Key concepts: Adefovir, Medicine, Gastroenterology, Internal medicine, Chronic hepatitis, Procollagen peptidase, Hepatic fibrosis, Hepatitis B