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2013•China Practical MedicineRequires access

The effectiveness of adefovir dipivoxil plus Interferon on serum IL-17 in patients with chronic hepatitis B

Chen Shu-mi

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Abstract

Objective To study the effectiveness of adefovir dipivoxil plus interferon on serum interleukin-17(IL-17) in patients with chronic hepatitis B.Methods 92 patients with chronic hepatitis B were randomly divided into two groups,the observation group(n=46 cases) and the control group(n=46 cases).The patients in the control group were treated through adefovir dipivoxil,while the patients in the observation group were treated through interferon plus adefovir dipivoxil for 12 months.Serum IL-17 were detected before and after treatment.Results ALT normalization,HBV-DNA negative rate and HbeAg negative rate in the observation group were higher these in the control group(P 0.05).Serum IL-17 in both groups were significantly decreased after treatment.It in the observation group was more significantly decreased than that in the control group(P 0.05).Conclusion Adefovir dipivoxil plus interferon can improve chronic hepatitis B through decreasing IL-17.

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What this paper is about

Objective To study the effectiveness of adefovir dipivoxil plus interferon on serum interleukin-17(IL-17) in patients with chronic hepatitis B.Methods 92 patients with chronic hepatitis B were randomly divided into two groups,the observation group(n=46 cases) and the control group(n=46 cases).The patients in the control group were treated through adefovir dipivoxil,while the patients in the observation group were treated through interferon plus adefovir dipivoxil for 12 months.Serum IL-17 were detected before and after treatment.Results ALT normalization,HBV-DNA negative rate and HbeAg negative rate in the observation group were higher these in the control group(P 0.05).Serum IL-17 in both groups were significantly decreased after treatment.It in the observation group was more significantly decreased than that in the control group(P 0.05).Conclusion Adefovir dipivoxil plus interferon can improve chronic hepatitis B through decreasing IL-17.

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Available abstract

Objective To study the effectiveness of adefovir dipivoxil plus interferon on serum interleukin-17(IL-17) in patients with chronic hepatitis B.Methods 92 patients with chronic hepatitis B were randomly divided into two groups,the observation group(n=46 cases) and the control group(n=46 cases).The patients in the control group were treated through adefovir dipivoxil,while the patients in the observation group were treated through interferon plus adefovir dipivoxil for 12 months.Serum IL-17 were detected before and after treatment.Results ALT normalization,HBV-DNA negative rate and HbeAg negative rate in the observation group were higher these in the control group(P 0.05).Serum IL-17 in both groups were significantly decreased after treatment.It in the observation group was more significantly decreased than that in the control group(P 0.05).Conclusion Adefovir dipivoxil plus interferon can improve chronic hepatitis B through decreasing IL-17.

Key concepts: Adefovir, Medicine, Chronic hepatitis, Gastroenterology, Internal medicine, HBeAg, Interferon, Hepatitis B

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