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An Immunohistochemistric Research on P_(53) Protein and Proliferating Cell Nuclear Antigen in Colorectal Cancer

Cao Ning-sh

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Abstract

Objective To clarify the relation between the expression of P 53 protein and proliferating cell nuclear antigen (PCNA) in colorectal cancer cells and its clinical pathology and prognosis. Methods P 53 protein and PCNA were detected in 48 patients with colorectal cancer by immunohistochemistric technique. Results The positive rates of expressing P 53 protein and PCNA were 56.3% and 93.8% respectively, and the strong PCNA-positive rate was 66.7%, which were correlated with the histological type, invasion depth and lymph node metastasis significantly (p0.05).Conclusions It is significant in combining detection of P 53 protein and PCNA for evaluating malignant degree, predicting lymph node metastasis trend and prognosis.

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What this paper is about

Objective To clarify the relation between the expression of P 53 protein and proliferating cell nuclear antigen (PCNA) in colorectal cancer cells and its clinical pathology and prognosis. Methods P 53 protein and PCNA were detected in 48 patients with colorectal cancer by immunohistochemistric technique. Results The positive rates of expressing P 53 protein and PCNA were 56.3% and 93.8% respectively, and the strong PCNA-positive rate was 66.7%, which were correlated with the histological type, invasion depth and lymph node metastasis significantly (p0.05).Conclusions It is significant in combining detection of P 53 protein and PCNA for evaluating malignant degree, predicting lymph node metastasis trend and prognosis.

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Available abstract

Objective To clarify the relation between the expression of P 53 protein and proliferating cell nuclear antigen (PCNA) in colorectal cancer cells and its clinical pathology and prognosis. Methods P 53 protein and PCNA were detected in 48 patients with colorectal cancer by immunohistochemistric technique. Results The positive rates of expressing P 53 protein and PCNA were 56.3% and 93.8% respectively, and the strong PCNA-positive rate was 66.7%, which were correlated with the histological type, invasion depth and lymph node metastasis significantly (p0.05).Conclusions It is significant in combining detection of P 53 protein and PCNA for evaluating malignant degree, predicting lymph node metastasis trend and prognosis.

Key concepts: Proliferating cell nuclear antigen, Colorectal cancer, Antigen, Lymph node metastasis, Lymph node, Medicine, Nuclear protein, Cancer research

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An Immunohistochemistric Research on P_(53) Protein and Proliferating Cell Nuclear Antigen in Colorectal Cancer — Research Paper | ScholarLens