Relationship between the Expression of Mutant P53 and PCNA and their Clinical Significances in Colorectal Cancer

Objective: To study the relationship between the expression of mutant P53(mp53)and proliferating cell nuclear antigen(PCNA)and their clinical significances in colorectal cancer.Methods: Immunohistochemistry was used to detect the expression of mu-tant p53 protein and PCNA in 60 tissues of colorectal cancer and 20 tissues of normal colorectal mucosa.The results were analysed with the clinical pathologic characters of colorectal cancer.Results: In the 60 tissues of colorectal cancer,the positive expression rate of mu-tant p53 and PCNA was 65.0% and 78.3%(P0.05).In the 20 tissues of normal colorectal mucosa,the expressions of mutant P53 protein and PCNA were negative(P0.05).In the group of lower differentiation,serosa invasion and lymph node metastasis of colorectal cancer,the positive expression rate of mutant p53 or PCNA was higher(P0.05).The expression of mutant P53 has positive correlation with the expression of PCNA(r=0.58,P0.05).Conclusion: The expression of mutant p53 or PCNA was correlated with differentiation,the depth of invasion and lymph node metastasis in colorectal cancer.therefore,they have prognostic value.