Correlation between serum soluble E-selectin,interleukin-10 and the degree of coronary artery lesions in acute coronary syndrome

Objective:To explore the correlation between the levels of soluble E-selectin(SES),interleukin-10(IL-10)and the degree of coronary artery stenosis in acute coronary syndrome(ACS).Methods:Ninety-four patients receiving coronery artery angiography were divided into ACS group(39 cases),stable angina pectoris(SAP)group(23 cases)and control group(32 cases).The serum levels of SES and IL-10 were measured by ELISA,and the high-sensitive creactive protein(hs-CRP)was dertermined by immunoturbidimetry.Results:The serum levels of SES and hs-CRP in ACS group were significantly higher than those in SAP group and control group(P0.01);the serum levels of SES and hs-CRP in SAP group had no significant difference compared with those of the control(P0.05).SES and IL-10 had no obvious correlation with the count of coronary athey stenosis or the degree of coronary artery stenosis(P0.05).Conclusions:Increased serum levels of SES and IL-10 may reflect the instability of atherosclerotic plaques but not the degree of coronary artery stenosis in acute coronary syndrome.