Value of measuring levels of serum soluble OX40 ligand and hs-CRP in predicting coronary artery events

Objective To explore the relationship between sOX40L,high sensitivity C reactive protein(hs-CRP) and stability of coronary atherosclerotic plaque in patients with coronary heart disease(CHD). Methods A total of 200 patients were divided into three groups:acute coronary syndrome(ACS) group, stable angina pectoris(SAP) group and control group. The plasma sOX40L was determined with ELISA and hs-CRP was measured with scatter nephelometry in all subjects. All patients underwent coronary angiography(CAG) and angiographic coronary stenosis morphology score was calculated. Results The serum levels of sOX40L and hs-CRP in ACS group were significantly higher than those in SAP and control groups (P 0.05) ,but there was no significant difference between SAP group and control group. The score of angiographic morphology of coronary lesions in ACS group was significantly higher than that in SAP and control groups (P 0.05), but there was no significant difference between SAP group and control group. The levels of sOX40L and hs-CRP were correlated with the coronary stenosis severity score (P 0.05). Correlation analysis indicated that the level of sOX40L was positively correlated with hs-CRP (P 0.05). Conclusion The increased serum levels of sOX40L and hs-CRP in ACS may enhance the inflammation,aggravate the development of atherosclerosis and mediate the rupture of instable plaque. They can serve as valuable markers for evaluating the degree of coronary artery pathology and predicting the occurrence of coronary artery events.