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2005•Journal of Zhengzhou UniversityRequires access

Expression of VEGF in gastric adenocarcinoma tissue

Huaisheng Wang

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Abstract

Aim: To investigate the expression of vascular endothelial growth factor(VEGF) in gastric adenocarcinoma tissue. Methods: The VEGF expression in 56 cases of gastric adenocarcinoma tissue,40 cases of atypical hyperplasia tissue adjacent to gastric adenocarcinoma and 56 cases of normal gastric tissue was detected using immunohistochemistry. Results: The positive rates of VEGF in gastric adenocarcinoma tissue, atypical hyperplasia tissue,and normal gastric tissue were 69.64%,45.00%, and 23.21%,respectively, and the difference between any two groups was significant(χ2= 54.47,P0.01); VEGF was correlated with the degree of the invasion depth, histological classification, lymphatic metastasis, and pathology period of gastric adenocarcinoma(P0.05 or 0.01); it had no correlation with age, sex or differentiation degree(P0.05). Conclusion: VEGF is correlated with the carcinogenesis, development,invasion and metastasis of gastric adenocarcinoma.

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What this paper is about

Aim: To investigate the expression of vascular endothelial growth factor(VEGF) in gastric adenocarcinoma tissue. Methods: The VEGF expression in 56 cases of gastric adenocarcinoma tissue,40 cases of atypical hyperplasia tissue adjacent to gastric adenocarcinoma and 56 cases of normal gastric tissue was detected using immunohistochemistry. Results: The positive rates of VEGF in gastric adenocarcinoma tissue, atypical hyperplasia tissue,and normal gastric tissue were 69.64%,45.00%, and 23.21%,respectively, and the difference between any two groups was significant(χ2= 54.47,P0.01); VEGF was correlated with the degree of the invasion depth, histological classification, lymphatic metastasis, and pathology period of gastric adenocarcinoma(P0.05 or 0.01); it had no correlation with age, sex or differentiation degree(P0.05). Conclusion: VEGF is correlated with the carcinogenesis, development,invasion and metastasis of gastric adenocarcinoma.

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Available abstract

Aim: To investigate the expression of vascular endothelial growth factor(VEGF) in gastric adenocarcinoma tissue. Methods: The VEGF expression in 56 cases of gastric adenocarcinoma tissue,40 cases of atypical hyperplasia tissue adjacent to gastric adenocarcinoma and 56 cases of normal gastric tissue was detected using immunohistochemistry. Results: The positive rates of VEGF in gastric adenocarcinoma tissue, atypical hyperplasia tissue,and normal gastric tissue were 69.64%,45.00%, and 23.21%,respectively, and the difference between any two groups was significant(χ2= 54.47,P0.01); VEGF was correlated with the degree of the invasion depth, histological classification, lymphatic metastasis, and pathology period of gastric adenocarcinoma(P0.05 or 0.01); it had no correlation with age, sex or differentiation degree(P0.05). Conclusion: VEGF is correlated with the carcinogenesis, development,invasion and metastasis of gastric adenocarcinoma.

Key concepts: Adenocarcinoma, Gastric adenocarcinoma, Atypical hyperplasia, Immunohistochemistry, Pathology, Medicine, VEGF receptors, Vascular endothelial growth factor

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