Expression of Hypoxia Inducible Factor-1α in Gastric Carcinoma and its Relationship with Vascular Endothelial Growth Factor

[Purpose] To explore the expression of hypoxia inducible factor-1α(HIF-1α) in gastric carcinoma and its relationship with vascular endothelial growth factor (VEGF). [Methods] The expression of HIF-1αand VEGF in 80 cases with gastric carcinoma, 30 cases with gastric paracarcinous tissue(mucosal atypical hyperplasia tissue) and 30 cases with normal gastric tissue(control groups) were detected by immunohistochemistry technique (SP). The relationship between the expression of HIF-1α, VEGF and clinicopathologic feature, prognosis of gastric carcinoma was analyzed. [Results] The positive expression rates of HIF-1αand VEGF in gastric carcinoma were 47.5%(38/80) and 71.3%(57/80) respectively, and both significantly higher than those in gastric paracarcinous tissue(mucosal atypical hyperplasia tissue) and the normal gastric tissue(P0.05). The expression of HIF-1αand VEGF in gastric carcinoma correlated to TNM stage, invasive depth and lymph-node metastasis(P0.05), not to histological grade. There was significantly correlation between HIF-1αand VEGF expression(γ=0.328,P0.01). [Conclusion] The over-expression of HIF-1α and VEGF in gastric carcinoma closely relates to invasion, metastasis and prognosis in gastric carcinoma. HIF-1α may play an important role in carcinogenesis of gastric carcinoma by up-regulate the expression of VEGF.