Distribution and drug resistance analysis of pathogenic bacteria in blood samples in a hospital from 2011 to 2012

Objective To understand the distribution and drug resistance of pathogenic bacteria in blood culture in this hospital from 2011 to 2012. Methods Blood samples were cultivated with Bact/Alert3D automated hemanalysis system, pathogenic bacteria were identified and drug sensitivity test was taken with VITEK 2 compact, the test results were analyzed with WHONET 5.4 software. Results Among the 8370 clinical blood samples, 719 strains of pathogenic bacteria were isolated, the positive rate was 8.6%, Gram-positive bacteria accounted for 62.4%, Gram-negative bacteria accounted for 32.9%, and fungi accounted for 4.4%. The highest detection rate in all bacteria were coagulase negative staphylococcus (42.3%), E.coli (15.8%) and staphylococcus aureus (10.0%) respectively. The staphylococcus were sensitive (100.0%) to vancomycin and linezolid. The enterobacteriaceae were sensitive (100.0%) to imipenem and meropenem. Conclusion Periodic surveillance of bacteria resistance is contributes to understand the changes of hospital bacterial resistance, and it has important significance to guided hospital for reasonable application of antimicrobial agents.