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2007•Journal of Taishan Medical CollegeRequires access

Effect of sodium vanadate on the proliferation of NIH3T3 cell line

Yan Shao-chun

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Abstract

Objective: To study the effects of sodium vanadate(SV) on the proliferation of NIH3T3 cell line at different concentration and duration.Methods: The cells were treated with different concentrations of SV and the proliferation of cells was detected by the method of MTT assay for different durations.Results: 0.1 μM of SC had no effect on proliferation of NIH3T3,1.010.0μM of SC enhanced the proliferation and 200 μM of SC promoted apoptosis,100 μM of SC had different effects for different druations.Conclusion: The exposure of NIH3T3 cells to SV leads to the proliferation or apoptosis depending on the dose-and time.

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Objective: To study the effects of sodium vanadate(SV) on the proliferation of NIH3T3 cell line at different concentration and duration.Methods: The cells were treated with different concentrations of SV and the proliferation of cells was detected by the method of MTT assay for different durations.Results: 0.1 μM of SC had no effect on proliferation of NIH3T3,1.010.0μM of SC enhanced the proliferation and 200 μM of SC promoted apoptosis,100 μM of SC had different effects for different druations.Conclusion: The exposure of NIH3T3 cells to SV leads to the proliferation or apoptosis depending on the dose-and time.

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Available abstract

Objective: To study the effects of sodium vanadate(SV) on the proliferation of NIH3T3 cell line at different concentration and duration.Methods: The cells were treated with different concentrations of SV and the proliferation of cells was detected by the method of MTT assay for different durations.Results: 0.1 μM of SC had no effect on proliferation of NIH3T3,1.010.0μM of SC enhanced the proliferation and 200 μM of SC promoted apoptosis,100 μM of SC had different effects for different druations.Conclusion: The exposure of NIH3T3 cells to SV leads to the proliferation or apoptosis depending on the dose-and time.

Key concepts: Apoptosis, Vanadate, Cell growth, Cell culture, Sodium, MTT assay, Chemistry, Cell

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