The different effects of lanthanum compound on the cell activity of tumor and normal tissue in vitro

Objective To investigate the effects of lanthanum chloride(LaCl3) on tumor cell lines and normal cell lines in vitro.Methods MTT was employed to detect the cell viability of Hela,Caski,HUVEC,as well as the ADSCs cells in vitro,these cells are all treated with LaCl3.Results The growth and proliferation of Hela cells were inhibited significantly by LaCl3 at the concentrations above 5μmol/L compared with the control group(P0.05);as for Caski cells,5μmol/L of LaCl3 improved its growth slightly,but the growth and proliferation were suppressed gradually when the dosages of LaCl3 increased from 25μmol/L(P0.05).LaCl3 did not show any cell toxicity to the HUVEC and ADSCs cells but promoted the proliferation of them in the certain concentration range.Conclusion A certain concentration of LaCl3 can inhibit the growth and proliferation of tumor cell lines,but it has the property of promoting the growth of normal cells meanwhile.