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Maternal blood group antibodies monitoring in prevention of ABO-HDN

Qi Yang

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Abstract

Objective To study the value of maternal blood group IgG antibody titer monitoring in prevention of ABO hemolytic disease of newborn (ABO-HDN).Methods To monitor sera IgG anti-(A) B antibody 938 cases of pregnant women with blood type O using improved anti-human globulin method and serological detection of hemolytic disease on high-risk newborns.Results When the valence of antibody was 1∶64,1∶128,1∶256 and more,the ABO-HDN incidence rates were 10.24%,43.24%,89.47% respectively.Statistically significants were detected between different antibody titers groups.Conclusion The more the titers of IgG andbody in the sera with pregnant women,the higher the incidence of ABO- HDN were.So the blood group IgG antibody titers monitoring were very important to the prevention of ABO-HDN in pregnance.

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What this paper is about

Objective To study the value of maternal blood group IgG antibody titer monitoring in prevention of ABO hemolytic disease of newborn (ABO-HDN).Methods To monitor sera IgG anti-(A) B antibody 938 cases of pregnant women with blood type O using improved anti-human globulin method and serological detection of hemolytic disease on high-risk newborns.Results When the valence of antibody was 1∶64,1∶128,1∶256 and more,the ABO-HDN incidence rates were 10.24%,43.24%,89.47% respectively.Statistically significants were detected between different antibody titers groups.Conclusion The more the titers of IgG andbody in the sera with pregnant women,the higher the incidence of ABO- HDN were.So the blood group IgG antibody titers monitoring were very important to the prevention of ABO-HDN in pregnance.

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Available abstract

Objective To study the value of maternal blood group IgG antibody titer monitoring in prevention of ABO hemolytic disease of newborn (ABO-HDN).Methods To monitor sera IgG anti-(A) B antibody 938 cases of pregnant women with blood type O using improved anti-human globulin method and serological detection of hemolytic disease on high-risk newborns.Results When the valence of antibody was 1∶64,1∶128,1∶256 and more,the ABO-HDN incidence rates were 10.24%,43.24%,89.47% respectively.Statistically significants were detected between different antibody titers groups.Conclusion The more the titers of IgG andbody in the sera with pregnant women,the higher the incidence of ABO- HDN were.So the blood group IgG antibody titers monitoring were very important to the prevention of ABO-HDN in pregnance.

Key concepts: ABO blood group system, Medicine, Antibody, Titer, Antibody titer, Immunology, Incidence (geometry), Blood type (non-human)

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