Study of the relationship between blood group antibody IgG titer of pregnant women and ABO-HDN

Objective:To study of the relationship between blood group antibody IgG titer of pregnant women and ABO hemolytic disease of newborn (HDN). Methods:Blood group antibody IgG titers of 2741 pregnant women who is O and Rh positive with a non-O husband were detected. After born, blood groups, Coomb's test, free antibody and antibody release test were done for those 286 babies who were in high risk of HDN, so that we could understand the relationship between the antibody IgG level of pregnant women and ABO-HDN. Results:The percent of anti-A(B) IgG titer 64, 64, 128, 256 and ≥512 in the 2741 O type pregnant women was 61.9%, 17.0%, 12.6%, 6.1% and 2.4%, respectively. There were 71 babies suffered from HDN in those 286 babies who had high risk, which accounted for 24.8%. With the anti-A(B) IgG titer was 64, 128, 256 and ≥512 , the percent of HDN positive was 10.7%, 28.3%, 44.9% and 64.3%, respectively (P0.01). Conclusion: There is a positive relationship between blood group antibody IgG titer of pregnant women and ABO-HDN. It is necessary for the pregnant women to detect the level of anti-A(B) IgG.