Relationship between maternal IgG antibody and hemolytic disease of newborn

Objective To study the relationship between the IgG antibody titer of pregnant women with blood type O and ABO hemolytic disease of newborn(ABO-HDN).Methods To monitor sera IgG anti-(A) B antibody 745 cases of pregnant women with blood type O using micro-column gel dynamic and serological detection of hemolytic disease on high-risk newborns.Results When the valence of antibody was 1∶64,1∶128,1∶256 and more,the ABO-HDN incidence rates were 10.32%、50.94%、85.71% respectively.Statistically significants were detected between different antibody titers groups.Conclusion The more the titers of IgG antibody in the sera withpregnant women,the higher the incidence of ABO-HDN.So the IgG antibody titers monitoring of pregnant women were very important to the prevention of ABO-HDN.