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Inhibition of interferon-α1b on human albumin-induced hepatic fibrosis in rats

Xi Chen

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Abstract

Objective To observe the effects of interferon-α1b on human albumin-induced hepatic fibrosis in rats.Methods The human albumin-induced hepatic fibrosis was made in rats and the animals were treated with interferon-α1b and colchicines.The serum hepatic fibrotic markers and the liver histopathological examination were routinely conducted.Results Interferon-α1b decreased the serum ALT and AST levels,increased the serum albumin level,decreased the LN,HA,IV-C and HyP levels,and improved the liver fibrosis histologically.Conclusion Interferon-α1b can inhibit the human albumin-induced hepatic fibrosis in rats.

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What this paper is about

Objective To observe the effects of interferon-α1b on human albumin-induced hepatic fibrosis in rats.Methods The human albumin-induced hepatic fibrosis was made in rats and the animals were treated with interferon-α1b and colchicines.The serum hepatic fibrotic markers and the liver histopathological examination were routinely conducted.Results Interferon-α1b decreased the serum ALT and AST levels,increased the serum albumin level,decreased the LN,HA,IV-C and HyP levels,and improved the liver fibrosis histologically.Conclusion Interferon-α1b can inhibit the human albumin-induced hepatic fibrosis in rats.

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Available abstract

Objective To observe the effects of interferon-α1b on human albumin-induced hepatic fibrosis in rats.Methods The human albumin-induced hepatic fibrosis was made in rats and the animals were treated with interferon-α1b and colchicines.The serum hepatic fibrotic markers and the liver histopathological examination were routinely conducted.Results Interferon-α1b decreased the serum ALT and AST levels,increased the serum albumin level,decreased the LN,HA,IV-C and HyP levels,and improved the liver fibrosis histologically.Conclusion Interferon-α1b can inhibit the human albumin-induced hepatic fibrosis in rats.

Key concepts: Albumin, Medicine, Fibrosis, Hepatic fibrosis, Interferon, Internal medicine, Serum albumin, Human serum albumin

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