2009•Pharmaceutical Journal of Chinese People's Liberation ArmyRequires access
Effects of Shugananlening Extract on the Hepatic Tissue of Hepatic Fibrosis Rats
Xia Ai
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Abstract
Aim To investigate the effects of Shugananlening Extract on hepatic tissue of hepatic fibrosis rats so as to provide experimental data for RD of new drugs. Methods Wistar rats were induced by subcutaneous injection CCl4 to produce a hepatic fibrotic model.With colchicines as control,the content of Hyp、MDA、SOD、GSH-Px was analyzed and the effects of Shugananlening on the morphous expression of hepatic tissue in hepatic fibrosis rats was investigated for the mechanism of anti-hepatic fibrosis. Results Shugananlening could remarkably inhibit the content of Hyp,MDA as well as advanced SOD、GSH-Px. Histomorphology pathological examination showed that Shugananlening could significantly reduce the degree of hepatic fibrosis in rats. Conclusion Shugananlening shows the anti-oxidation lipid and anti-hepatic fibrosis function.HD(high dose) is optimial. The mechanism is supposed to relate to inhibition of collagen protein and removal of free radical and anti-oxidation lipid.