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Establishment of the progressive and recovery fibrosis model in rats induced by carbon tetrachloride

Peng Zhu

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Abstract

Aim To establish the model of progression and recovery of hepatic fibrosis in rats.Methods Progressive and recovery fibrosis model was induced by subcutaneous injection of CCl4.The levels of HA,LN,Ⅳ-C and PCⅢ in serum and Hyp in liver were observed.Results Histological analysis of the livers harvested after treatment CCl48,12,16 weeks showed pathologic change of chronic hepatics,hepatic fibrosis and hepatic cirrhosis,respectively.Meanwhile,the levels of HA,LN,Ⅳ-C and PCⅢ in serum and the Hyp in liver were elevated gradually.Whereas,with recovery from fibrosis,the levels of HA,LN,Ⅳ-C and PCⅢ in serum and the Hyp in liver were markedly diminished and pathologic change of hepatic tissue was improved.Conclusion The model of progression and recovery of hepatic fibrosis is successfully established.

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What this paper is about

Aim To establish the model of progression and recovery of hepatic fibrosis in rats.Methods Progressive and recovery fibrosis model was induced by subcutaneous injection of CCl4.The levels of HA,LN,Ⅳ-C and PCⅢ in serum and Hyp in liver were observed.Results Histological analysis of the livers harvested after treatment CCl48,12,16 weeks showed pathologic change of chronic hepatics,hepatic fibrosis and hepatic cirrhosis,respectively.Meanwhile,the levels of HA,LN,Ⅳ-C and PCⅢ in serum and the Hyp in liver were elevated gradually.Whereas,with recovery from fibrosis,the levels of HA,LN,Ⅳ-C and PCⅢ in serum and the Hyp in liver were markedly diminished and pathologic change of hepatic tissue was improved.Conclusion The model of progression and recovery of hepatic fibrosis is successfully established.

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Available abstract

Aim To establish the model of progression and recovery of hepatic fibrosis in rats.Methods Progressive and recovery fibrosis model was induced by subcutaneous injection of CCl4.The levels of HA,LN,Ⅳ-C and PCⅢ in serum and Hyp in liver were observed.Results Histological analysis of the livers harvested after treatment CCl48,12,16 weeks showed pathologic change of chronic hepatics,hepatic fibrosis and hepatic cirrhosis,respectively.Meanwhile,the levels of HA,LN,Ⅳ-C and PCⅢ in serum and the Hyp in liver were elevated gradually.Whereas,with recovery from fibrosis,the levels of HA,LN,Ⅳ-C and PCⅢ in serum and the Hyp in liver were markedly diminished and pathologic change of hepatic tissue was improved.Conclusion The model of progression and recovery of hepatic fibrosis is successfully established.

Key concepts: Carbon tetrachloride, Cirrhosis, Hepatic fibrosis, Fibrosis, CCL4, Subcutaneous injection, Pathology, Rat model

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Establishment of the progressive and recovery fibrosis model in rats induced by carbon tetrachloride — Research Paper | ScholarLens