Serum soluble cell adhesion molecules in patients with coronary heart disease

Objective:To explore the significance of cellular adhesion molecules (CAMs) in coronary heart disease (CHD) by measuring serum soluble intercellular adhesion molecule 1 (sICAM 1) and P selectin (Ps) levels in patients with CHD. Method:By means of enzyme linked immunosorbent assay (ELISA), the concentrations of serum sICAM 1 and Ps were measured in 68 patients with CHD as well as in 55 controls. The Gensini scoring system was used to determine the severity of coronary artery lesions. Result:The concentrations of sICAM 1 and Ps were significantly higher in CHD patients than those in controls (both P 0.001 ). A significant correlation between the severity of the coronary artery lesions and the levels of serum sICAM 1 and total cholesterol (TC) was found from the multiple regression analysis (P 0.001 and P 0.01 ). The concentration of triglyceride (TG) might influence the level of serum sICAM 1. Conclusion:ICAM 1 and Ps may involve in the pathogenesis of coronary heart disease. Serum sICAM 1 may be an available index for the severity of CHD.