Treatment of 45 cases of advanced colorectal cancer with "Yiqi Jiedu Decoction" and CapeOX chemotherapy

Objective To observe the clinical efficacy and safety of Yiqi Jiedu Decoction and CapeOX chemotherapy in treating advanced colorectal cancer.Methods Ninety cases were randomly divided into two groups: treatment group in which 45 cases were treated with Yiqi Jiedu Decoction and CapeOX chemotherapy,and control group in which 45 cases were treated with CapeOX chemotherapy alone,with a course of 42 days.The clinical effects,TCM syndromes and quality of life score after treatment,NK cells,T cell subsets changes were observed.Time to tumor progression(TTP),overall survival(OS) and 1-year survival rate were observed one year after treatment.Results The total effective rates(CR + PR) in treatment group and control group were 44.44% and 37.78% respectively,with no difference between the two groups(P0.05).There were significant differences in the clinical benefit rate,median time to progression,median survival time,1-year survival rate,TCM symptom improvement rate,quality of life(KPS) and the improvement of immune parameters between the two groups(P0.05).There were also significant differences in leukopenia decrease and occurrence of nausea and vomiting between the two groups(P0.05).Conclusion Combined Yiqi Jiedu Decoction and CapeOX chemotherapy can control tumor progression,improve the clinical benefit rate,prolong survival period,improve clinical symptoms and quality of life,immune function,and reduce postchemotherapeutic side effects in the treatment of advanced colorectal cancer.