2009•Lishizhen Medicine and Materia Medica ResearchRequires access

Antiangiogenesis Effect of Ascorbic Acid SesquioxyGe(IV) on Chicken Embryo Chorioallantoic Membrane

Jiqing Zhang

Abstract

Objective To investigate the antiangiogenesis effect of the ascorbic Acid SesquioxyGe(Ⅳ) on chicken embryo chorioallantoic membrane(CAM).Methods The ascorbic acid SesquioxyGe(Ⅳ) loaded with methylcellulose membranes was applied on chicken CAM surface of 7-day-old eggs and incubated for 48 hours.Local vessel density was measured under dissection microscope.The inhibitory effect on CAM angiogenesis was evaluated.Results The Ge(Ⅳ) complex with ascorbic acid at 2.5,1.5 mg/egg and 0.5 mg/egg dose-dependently decreased the density of local blood vessels.Conclusion Ascorbic acid SesquioxyGe(Ⅳ) significantly inhibits chicken CAM angiogenesis.

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Key concepts: Chorioallantoic membrane, Ascorbic acid, Embryo, Angiogenesis, Chemistry, Andrology, Biology, Biochemistry