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Improvement of chick chorioallantoic membrane technique

Hu Qun

Open publisher page 1 citations

Abstract

Objective: To improve the technique of chick chorioallantoic membrane (CAM). and establish a good vascular model in vivo for screening antiangiogenesis drugs. Methods: In improving the traditional CAM technique, 3 days'chick embryo was removed out and placed onto plate for further development. After incubating on the plate for 3 days, drugs to be screened were grafted onto CAM and YSM (yolk sac membrane, YSM). The effect, of drugs on CAM and YSM were examined after 24 hours. Results: after 6 days incubation, the survival ratio of chick embryo was 46.7% and growth condition is good. The diameter of CAM reached 1.2cm. The evident responses of antiangiogenesis and chemotaxis were found in the groups of 6 drugs. Conclusion: The technique of incubating CAM in plate have wide application value in researching the vascular effects of drugs, bio factors, tumors, and so on.

About this research paper

What this paper is about

Objective: To improve the technique of chick chorioallantoic membrane (CAM). and establish a good vascular model in vivo for screening antiangiogenesis drugs. Methods: In improving the traditional CAM technique, 3 days'chick embryo was removed out and placed onto plate for further development. After incubating on the plate for 3 days, drugs to be screened were grafted onto CAM and YSM (yolk sac membrane, YSM). The effect, of drugs on CAM and YSM were examined after 24 hours. Results: after 6 days incubation, the survival ratio of chick embryo was 46.7% and growth condition is good. The diameter of CAM reached 1.2cm. The evident responses of antiangiogenesis and chemotaxis were found in the groups of 6 drugs. Conclusion: The technique of incubating CAM in plate have wide application value in researching the vascular effects of drugs, bio factors, tumors, and so on.

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Available abstract

Objective: To improve the technique of chick chorioallantoic membrane (CAM). and establish a good vascular model in vivo for screening antiangiogenesis drugs. Methods: In improving the traditional CAM technique, 3 days'chick embryo was removed out and placed onto plate for further development. After incubating on the plate for 3 days, drugs to be screened were grafted onto CAM and YSM (yolk sac membrane, YSM). The effect, of drugs on CAM and YSM were examined after 24 hours. Results: after 6 days incubation, the survival ratio of chick embryo was 46.7% and growth condition is good. The diameter of CAM reached 1.2cm. The evident responses of antiangiogenesis and chemotaxis were found in the groups of 6 drugs. Conclusion: The technique of incubating CAM in plate have wide application value in researching the vascular effects of drugs, bio factors, tumors, and so on.

Key concepts: Chorioallantoic membrane, Embryo, Incubation, In vivo, Biology, Chemotaxis, Yolk sac, In vitro

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