A comparative study of citalopram angument with olanzapine in the treatment of refractory depression

Objective To explore the efficacy of citalopram angument with olanzapine in the treatment of refractory depression.Methods A total of 67 patients with refractory depression were randomly divided into study group with citalopram combined with olanzapine and control group with citalopram for 12 weeks of treatment.They were assessed and analysed contrastively using Hamilton Depression Scale(HAMD),Hamilton Anxiety Scale(HAMA)for clinical efficacy and Treatment Emergent Symptom Scale(TESS)for side effects.Results After treatment,the scores of HAMD and HAMA in two groups were both significantly lower than those before treatment.In the 1st,2nd,4th,6th and 12th weekend of treatment,the scores of HAMD and HAMA in study group were significantly lower than those in control group.No severe side effects were found in two groups.Conclusion Citalopram augmented with olanzapine takes effects better and faster than citalopram single and doesn't increase side effects in the treatment of refractory depression.