Curative Effect Comparison Between Mifepristone and Desogestrel-ethinylestradiol in Perimenopausal Dysfunctional Uterine Bleeding

Objective To evaluate the clinical therapeutic effects of mifepristone versus desogestrel-ethinylestradiol in treatment of perimenopausal dysfunctional uterine bleeding. Methods Seventy patients with perimenopausal dysfunctional uterine bleeding were randomly divided into mifepristone group(n=36) and desogestrel-ethinvlestradiol group(n=34).After the treatment,the curative effects of the two groups were compared. Results After the treatment,normal menstrual cycles restored and the amount of blood loss reduced,there was no significant difference between the two groups (P0.05).E2 and progesterone levels decreased significantly in both groups(P0.05),but follicle-stimulating hormone,luteinizing hormone,and testosterone levels did not change significantly(P0.05).The incidence of amenorrhea,recurrence rate and the average increase value of hemoglobin in patients treated with mifepristone were all higher than those with desogestrel-ethinylestradiol(P0.05). Conclusions Oral administration of mifepristone or desogestrel-ethinylestradiol is efficient and feasible for perimenopausal dysfunctional uterine bleeding,which is worthy to be popularized in clinical practice.