Mifepristone vs.Desogestrel-ethinylestradiol for Patients with Perimenopausal Dysfunctional Uterine Bleeding:Comparison of Curative Effects

OBJECTIVE:To evaluate the clinical effects of mifepristone versus desogestrel-ethinylestradiol in treatment of patients with perimenopausal dysfunctional uterine bleeding. METHODS: Seventy-four patients with perimenopausal dysfunctional uterine bleeding were randomly divided into two groups: 39 were assigned to receive mifepristone and 35 to receive desogestrel-ethinylestradiol. RESULTS: After treatment, normal menstrual cycles restored, amount of blood loss reduced, E2 and progesterone levels decreased in both group, showing no significant differences between two groups (P0.05). However, incidence of amenorrhea and degree of endometrium atrophy were higher in patients treated with mifepristone than in those with esogestrel-ethinylestradiol(P0.05). CONCLUSION: Oral mifepristone or desogestrel-ethinylestradiol is efficient and feasible for perimenopausal dysfunctional uterine bleeding. However, mifepristone is suitable for patients approaching menopausal period, while desogestrel-ethinylestradiol is preferable for patients in the initial perimenopausal period.