2011•Linchuang huicuiRequires access
Effect of telmisartan on insulin resistance in patients with essential hypertension and impaired glucose regulation
Yi Zhao
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Abstract
Objective To explore the effect of telmisartan on insulin resistance in patients with essential hypertension and impaired glucose regulation.Methods 30 patients orally received telmisartan and another 30 patients received nifedipine for 6 months.The changes of glucose metabolism and insulin resistance were observed.Results We observed a significant decrease of patients with orally receiving telmisartan in the level of fasting insulin(9.7±4.3) mU/L,(8.0±3.9) mU/L,respectively(P0.05),postprandial 2 h blood sugar(8.9±1.6) mmol/L,(7.3±0.8) mmol/L,respectively(P0.05) and HOMA-IR 2.4±1.0,1.6±0.6 respectively(P0.05).There was significant difference in the above parameters between two groups after treatment(8.0±3.9) mU/L vs(9.6±3.5) mU/L(P0.01),(7.3±0.8) mmol/L vs(8.8±0.5) mmol/L(P0.05),1.6±0.6 vs 2.4±0.9(P0.05).There was no change in patients with nifedipine(all P0.05).Conclusion Telmisartan can improve insulin sensitivity in patients with essential hypertension and impaired glucose regulation.