Effect of Telmisartan on Glucose Metabolism in Aged Hypertensive Patients with Metabolic Syndrome

Objective To investigate the effect of telmisartan on glucose metabolism in aged hypertensive patients with metabolic syndrome.Methods Seventy aged patients with mild or moderate hypertension complicated by metabolic syndrome were divided randomly into groups T(telmisartan) and N(nifedipine),35 in each.T group were treated with telmisartan(40 mg/d),and N group with nifedipine(30 mg/d),6 months.The changes of glucose and lipid metabolism were compared between pre-and post-treatments.Results Blood pressure was well controlled in 2 groups,the difference in systolic and diastolic blood pressure was not significant between pre-and post-treatments(P0.05).In T group,pre-and post-treatment fasting insulin(10.4±4.4 μU/ml,6.8±2.3 μU/ml,respectively),postprandial 2 h blood glucose(8.7±1.3 mmol/L,7.1±0.9 mmol/L,respectively) and HOMA-IR(2.5±1.2,1.7±0.7,respectively) decreased significantly(P0.01),and early insulinogenic index(△I30/△G30) increased significantly(10.4±1.9,15.7±2.9,respectively)(P0.01);There was significant difference in the above parameters between 2 group after treatment(P0.01).No obvious changes were noted in pre-and post-treatment glucose and lipid metabolism in N group.Conclusion Telmisartan can not only decrease blood pressure but also improve insulin sensitivity and early insulin secretion function in aged patients with hypertension complicated by metabolic syndrome.