ScholarLens Back to search
2011•Chinese Heart JournalRequires access

Effects of telmisartan on insulin resistance and serum retinol-binding protein 4 in patients with essential hypertension

Yuan Zhong

Open publisher page 0 citations

Abstract

AIM: To investigate the effects of telmisartan on insulin resistance and serum retinol-binding protein 4 in patients with essential hypertension.METHODS: Forty-five subjects with essential hypertension were treated with telmisartan(80 mg/day) or losartan(100 mg/day) combined with long-acting calcium antagonist,if necessary,for 16 weeks.Waist and hip circumference,body mass index,blood pressure,fasting plasma glucose(FPG),insulin(FPI),lipid and retinol-binding protein 4(RBP4) were measured before and after the treatment.Insulin sensitivity was estimated by homeostasis model assessment(HOMA-IR).RESULTS: Compared with baseline levels,systolic and diastolic blood pressure decreased significantly in both groups.But the levels of HOMA-IR and RBP4 decreased significantly only in telmisartan group.CONCLUSION: Telmisartan improves insulin resistance and decreases serum RBP4 level in patients with essential hypertension.

About this research paper

What this paper is about

AIM: To investigate the effects of telmisartan on insulin resistance and serum retinol-binding protein 4 in patients with essential hypertension.METHODS: Forty-five subjects with essential hypertension were treated with telmisartan(80 mg/day) or losartan(100 mg/day) combined with long-acting calcium antagonist,if necessary,for 16 weeks.Waist and hip circumference,body mass index,blood pressure,fasting plasma glucose(FPG),insulin(FPI),lipid and retinol-binding protein 4(RBP4) were measured before and after the treatment.Insulin sensitivity was estimated by homeostasis model assessment(HOMA-IR).RESULTS: Compared with baseline levels,systolic and diastolic blood pressure decreased significantly in both groups.But the levels of HOMA-IR and RBP4 decreased significantly only in telmisartan group.CONCLUSION: Telmisartan improves insulin resistance and decreases serum RBP4 level in patients with essential hypertension.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

AIM: To investigate the effects of telmisartan on insulin resistance and serum retinol-binding protein 4 in patients with essential hypertension.METHODS: Forty-five subjects with essential hypertension were treated with telmisartan(80 mg/day) or losartan(100 mg/day) combined with long-acting calcium antagonist,if necessary,for 16 weeks.Waist and hip circumference,body mass index,blood pressure,fasting plasma glucose(FPG),insulin(FPI),lipid and retinol-binding protein 4(RBP4) were measured before and after the treatment.Insulin sensitivity was estimated by homeostasis model assessment(HOMA-IR).RESULTS: Compared with baseline levels,systolic and diastolic blood pressure decreased significantly in both groups.But the levels of HOMA-IR and RBP4 decreased significantly only in telmisartan group.CONCLUSION: Telmisartan improves insulin resistance and decreases serum RBP4 level in patients with essential hypertension.

Key concepts: Telmisartan, Internal medicine, Insulin resistance, Medicine, Endocrinology, Blood pressure, Essential hypertension, Losartan

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Effects of telmisartan on insulin resistance and serum retinol-binding protein 4 in patients with essential hypertension — Research Paper | ScholarLens