Changes and clinical significance of serum tumor necrosis factor-α and interleukin-10 in patients with acute cerebral infarction combined with systemic inflammatory response syndrome

Objective To observe the changes of serum tumor necrosis factor-α(TNF-α)and interleukin-10(IL-10)in patients with acute cerebral infarction(ACI)combined with systemic inflammatory response syndrome(SIRS),and to study the relationship to multiorgan dysfunction syndrome(MODS)and death rates.Methods One hundred and four patients with ACI were divided into SIRS(39 cases)and non-SIRS(65 cases)group.3 mL venous blood were took on empty stomach at morbidity 24 h,3 d,7 d and 14 d to determine serum TNF-α and IL-10 by radioimmunoassay,and incidence rates of MODS and death rates were observeed in two groups.Results There was no significant difference in serum TNF-α at morbidity 24 h,3 d,7 d and 14 d in no-SIRS group(P=0.193),but there was significant difference in SIRS group(P=0.032).The serum TNF-α was higher obviously in SIRS group than this in non-SIRS group at different time(P=0.000).There was significant difference in serum IL-10 at different time in two groups(P=0.000).The serum IL-10 was higher obviously in SIRS group than this in non-SIRS group(P=0.009),it was higher in SIRS group than this in non-SIRS group at morbidity 24 h,3 d and 7 d,but there was no significant difference between two groups at 14 d(P=0.095).The incidence rates of MODS and death were higher obviously in SIRS group than this in non-SIRS group(P=0.025,P=0.005).Conclusion TNF-α and IL-10 participate in the occurrence and development of SIRS after cerebral infarction.They can be regarded as prophase index of predicting MODS.