Clinical Significance of Changes of Serum TNF-α and IL-6 Levels in Acute Cerebral Hemorrhage Patients with Systemic Inflammatory Response Syndrome

Objective To investigate the clinical significance of changes of serum TNF-α and IL-6 levels in acute cerebral hemorrhage patients with systemic inflammatory response syndrome. Methods A total of 127 patients with acute cerebral hemorrhage were divided into SIRS group(n=60) and non-SIRS group(n=67).All of the patients were all phlebotomized 3 ml of fasting venous blood in the morning within 24 hours after the incidence of the disease,and at 3,7 and 14 days.The levels of serum TNF-α and IL-6 were determined by ELISA and the incidence and mortality rates of MODS of the two groups were observed. Results Differences of serum TNF-α level in the patients of SIRS group were statistically significant at different time points(P0.01),TNF-α achieved its peak value at 7 days in SIRS group,and it was significantly higher in SIRS group than in non-SIRS group at any time points.Differences of serum IL-6 level in all patients with cerebral hemorrhage were statistically significant at different time points(P0.01),IL-6 achieved its peak value at 3 days in both SIRS and non-SIRS groups,and as time went by,its value was decreasing,but IL-6 was still significantly higher in SIRS group than in non-SIRS group at any time points(P0.01).The mortality rate of SIRS group reached 55%(33/60),while the mortality rate of non-SIRS group was only 7.46%(5/67).Multiple organ dysfunction syndrome(MODS) occurred in 36%(22/60) patients of SIRS group and in 4.48%(3/67) patients of non-SIRS group.There were significantly differences in mortality rate and MODS between the two groups(χ2=11.39,χ2=9.87,P0.01). Conclusions TNF-α and IL-6 participate in the occurrence and development of SIRS after cerebral hemorrhage,and have a high foretell value to cerebral hemorrhage accompanied with or without MODS.