Study on the cytokines of acute cerebral hemorrhage complicated with systemic inflammatory response syndrome

Objective To observe TNF-αand IL-10 of systemic inflammatory response syndrome(SIRS)after acute cerebral hemorrhage,and their relations with multiple organ dysfunction syndrome(MODS)and mortality rate.Methods A total of 60 cases with acute cerebral hemorrhage were divided into SIRS group(28 cases)and non-SIRS group(32 cases),who were all phlebotomized 3 mL of fasting venous blood in the morning within 24h after the incidence of the disease,and at 3,7 and 14d.The levels of serum TNF-αand IL-10 were determined by RIA and the incidence and mortality rates of MODS of the two groups were observed.Results Differences of TNF-αin all patients with cerebral hemorrhage were statistically significant at different time points(P=0.000),TNF-αachieved its peak value at 3d and 7d in SIRS group,and it was comparatively higher in SIRS group than non-SIRS group at any time points(P=0.000).Differences of IL-10 in all patients with cerebral hemorrhage were statistically significant at different time points(P=0.000),IL-10 achieved its peak value at 3d in both SIRS and non-SIRS groups,and as time went by,its value was decreasing,but IL-10 was still relatively higher in SIRS group than non-SiRS group at any time points(P=0.000).Ten cases in SIRS group developed MODS and only two cases,in non-SiRS group,so the differences between the two groups were significant(P=0.004);15 cases in SIRS group died and only three cases,in non-SIRS group,so the differences were also significant(P=0,000).Conclusion TNF-αand IL-10 participate in the occurrence and development of SIRS after cerebral hemorrhage.They can be regarded as the early indicators for the prediction of MODS.