Changes of serum C-reaction protein,interleukin-6 and D-Di in patients with neurology critically ill combined with systemic inflammatory response syndrome

Objective To observe the changes of serum C-reaction protein( CRP),interleukin-6( IL-6) and D-Di( D-Di) in patients with neurology critically ill combined with systemic inflammatory response syndrome( SIRS),and study the relationship to multiorgan dysfunction syndrome( MODS) and fatality rates. Methods In a prospectie case-control study,120 patients with neurology critically ill were divided into SIRS( 48 cases) and non SIRS( 72 cases) group. 5 mL venous blood were took during the fasting at morbidity 24 h,3 d and 7 d to determine serum CRP,IL-6,D-Di,and incidence rates of MODS and fatality rates were observed in two groups. Results There was no significant difference in serum CRP at morbidity 24 h,3 d and 7 d in non SIRS group( P 0. 05),but there was significant difference in SIRS group( P 0. 05). The serum CRP in SIRS group was higher obviously than that in non SIRS group at different time( P 0. 01). The serum IL-6 in SIRS group was higher obviously than that in non SIRS group at different time( P 0. 01). There was no significant difference in serum D-Di at morbidity 24 h,3 d and 7 d in non SIRS group( P 0. 05),but there was significant difference in SIRS group( P 0. 05). The serum D-Di in SIRS group was higher obviously than that in non SIRS group at different time( P 0. 01). The incidence rate of MODS was higher obviously in SIRS group than that in non SIRS group( χ2= 5. 042,P 0. 05). The fatality rate was higher obviously in SIRS group than that in non SIRS group( χ2= 7. 879,P 0. 05). Conclusion Serum CRP,IL-6 and D-Di can be regarded as indexes of predicting MODS.