The correlation research of serum cystatin C,glomerular filtration rate(e-GFR)and urinary albumin creatinine ratio in diabetic nephropathy

Objective To investigate the correlation of diabetic nephropathy serum cystatin C(Cys-C),and glomerular filtration rate(e-GFR),urinary albumin creatinine ratio(m-Alb/Cr).Methods Detect 121 cases of diabetic nephropathy patients and 60 normal controls for serum cystatin C,glomerular filtration rate,urinary albumin creatinine ratio,according to different levels of serum cystatin C group,compare the serum cystatin C,glomerular filtration rate,urinary albumin creatinine ratio sensitivity and relativity.Results In diabetic nephropathy group and the normal control group,the level of serum cystatin C showed significant differences(p0.05);cystatin C in different groups,the diabetic nephropathy group A and the normal control group,urinary m-Alb/Cr had significant differences(p0.05),diabetic nephropathy group B group and control group A between the Cys-C,e-GFR,m-Alb/Cr three indexes were significantly different(p0.01);cystatin C while e-GFR abnormal,with a good correlation between the two.Conclusion The sensitivity of urine m-Alb/Cr was significantly higher than serum Cys-C and e-GFR in diabetic nephropathy;serum cystatin C while e-GFR abnormal exist obvious correlated,cystatin C in the course of prosecution of diabetic nephropathy has a very good value.