The correlation research of serum cystatin C,glomerular filtration rate(e-GFR) and urinary albumin creatinine ratio in Diabetic nephropathy

Objective:To investigate the correlation of serum cystatin C(Cys-C),glomerular filtration rate(e-GFR),urinary albumin creatinine ratio(m-Alb/Cr) in diabetic nephropathy.Methods:121 diabetic nephropathy patients and 60 normal controls were detected for serum Cys-C,e-GFR,urinary m-Alb/Cr,according to different levels of serum Cys-C group,sensitivity and relevance of serum Cys-C,e-GFR and urinary m-Alb/Cr were compared.Results:The level of serum Cys-C between diabetic nephropathy group and the normal control group showed significant differences(P0.05);In different groups of serum Cys-C,compared with the diabetic nephropathy group A and the normal control group,the urinary m-Alb/Cr showed significant differences(P 0.05),and compared with diabetic nephropathy group A,diabetic nephropathy group B and control group,the three indexes including the Cys-C,e-GFR,m-Alb/Cr were significantly different(P0.01);While e-GFR was abnormal,the Cys-C and e-GFR had a good correlation.Conclusion:The sensitivity of urine m-Alb/Cr was significantly higher than serum Cys-C and e-GFR in diabetic nephropathy;Serum Cys-C had obvious correlation with e-CFR when e-CFR was abnormal,serum Cys-C had good value in the process of monitoring of diabetic nephropathy.