The Valuation of Serum Cystatin C in Early Diagnoses of Diabetic Nephropathy

OBJECTIVE To explore the valuation of serum cystatin c in early diagnoses of diabetic nephropathy.METHODS 120 cases of type 2 diabetic patients were divided into two groups by testing urinary albumin excretion(UAE),60 cases UAE negative was named as Group A;60 cases UAE positive as Group B;and 60 cases healthy persons as the control group.The concentration of serum cystatin c and creatinine were determined in all groups.The results of diabetic groups were compared with the control group respectively.The detection rate of cystatin c compared with that of creatinine.RESULTS Serum cystatin c and creatinine concentrations in diabetic patients were significantly higher than those in the controls(P0.01).In diabetic patients the detection rate of cystatin c was higher than that of creatinine.Group A:20% and 3%,Group B:41.7% and 8.3% respectively(P0.01).And the detection rate of cystatin c of group B was higher than that of Group A(P0.01).In Group A,patients of more than 5 years diabetic duration were compared with those less than 3 years diabetic duration,the cystatin c detection rate of the former was higher(P0.01).CONCLUSIONS Serum cystatin c is a more sensitive marker to reveal the damage of glomerular filtration rate in early stage of diabetic nephropathy.