The effeet and safety of Carboprost on prevention postpartum hemorrhage in high risk pregnant women

Objective To investigate the effect and safety of carboprost on prevention postpartum hemorrhage in high risk pregnant women.Methods 91 patients with high risk to postpartum hemorrhage were randomly divided into two groups.The control group were given with oxytocin intravascularly and the study group was given with carboprost and with oxytocin intravascularly.Carboprost was injected into cervix after fetal disengagement.The differences of amount of bleeding during different time between the two groups were compared.Results The amount of bleeding in study group of different time was obviously less than the control group,with(210.0±19.5)ml VS(312.5±38.7)ml after 2hs,and(361.0±130.5)ml VS(525.6±110.8)ml after 24hs.The incidence rate of postpartum hemorrhage and blood transfusion was much lower in study group(6.98%and 2.33%) than that in controlgroup(22.92%and 14.58%).The differences were of statistical significance(P0.05).Conclusion The preventive use of carboprost in high risk pregnant women to postpartum hemorrhage attained much better effects,and reduced the incidence rate of postpartum hemorrhage and blood transfusion.