Clinical observation of Carboprost combined with Oxytocin in prevention and treatment of postpartum hemorrhage

Objective:To observe the efficacy of Oxytocin and Carboprost(Carboprost Methylate Suppositories) in prevention postpartum hemorrhage of vaginal delivery.Methods:202 cases of puerperal puerperas in our hospital were randomly divided into observation group(n=102) and control group(n=100) from August 2006 to November 2010.Oxytocin was given to both groups for treatment after fetal childbirth immediately,and on the basis of it,a piece of Carboprost(1 mg) was given into rectum in observation group.The third stage of labor time,2 h postpartum hemorrhage volume,24 h postpartum hemorrhage volume and incidence of postpartum hemorrhage were compared between the two groups.Results:The third stage of labor time was(5.70±2.80) min,2 h postpartum hemorrhage volume was(149.5±30.0) ml,24 h postpartum hemorrhage volume was(210.8±57.6) ml in observation group,and the third stage of labor time was(9.98±3.50) min,2 h postpartum hemorrhage volume was(180.7±41.2) ml,24 h postpartum hemorrhage volume was(37.0±78.7) ml in control group,two groups of comparisons,the differences were statistically significant(t=2.596,4.832,7.489,P0.05).The incidence of postpartum hemorrhage of observation group was 1.96%(2/102),and the incidence of postpartum hemorrhage of control group was 8.00%(8/100),two groups of comparisons,the difference was statistically significant(χ2=4.393,P0.05).Conclusion:The efficacy of Oxytocin combined with Carboprost in prevention of postpartum hemorrhage is good,the drug use is simple,convenience and safety.It is worthy of clinical popularized.