Distribution and drug resistance of pathogens isolated from wounds of burn patients

OBJECTIVE To investigate the distribution and drug resistance of the pathogens isolated from the wounds of the burn inpatients during the 3 years so as to guide the reasonable use of antibiotics.METHODS A total of 324 burn patients who enrolled the hospital from Jan 2008 to Jan 2011 were cultured for the wounds,the etiology and the results of the drug susceptibility testing were analyzed.RESULTS Among 324 burn inpatients,there were 286 patients who were with wound infections.Totally 298 strains of pathogens were isolated,including 219 strains of gram-positive strains(73.5%),63 strains of gram-negative strains(21.1%)and 16 strains of fungi(5.4%).The top three species of pathogens were Pseudomonas aeruginosa(25.84%),Escherichia coli(18.12%),and Acinetobacter baumannii(14.43%).Among the non-fermenting bacteria,the multidrug-resistant rates of P.aeruginosa and A.baumannii were as high as 71.43% and 86.05%,respectively.Both of them were more sensitive to amikacin and cefoperazone/sulbactam,while more resistant to fluoroquinolone and a variety of third-generation cephalosporins.The positive rates of ESBLs-producing E.coli and K.pneumoniae were 75.93% and 79.71%.Among the gram-positive bacteria,the isolation rates of MRSE and MRSA were 71.43% and 72.00%,respectively.The Staphylococci were more resistant to penicillin and erythromycin,but more sensitive to vancomycin and linezolid.Candida albicans was the major fungi in burn patients.CONCLUSION The gram-negative bacteria are still the predominant pathogens isolated from the burn patients,while the isolation rates of the gram-positive bacteria and fungi are increasing gradually.The drug resistance of the pathogens is so serious that it is crucial for the reasonable use of antibiotics to monitor the drug resistance of the pathogens in a timely manner.