Association of A561C polymorphism of the E-selectin with myocardial infarction and serum lipid levels in Chinese elderly

Objective To study the relation between polymorphism of E selectin gene A561C and myocardial infarction (MI) in Wuhan area, China, and to analyse its relation with plasma lipoprotein. Methods Using polymerase chain reaction restriction fragment length polymorphism (PCR RFLP), E selectin A561C genotype was performed in 198 elderly and 187 middle aged patients with myocardial, and 190 elderly and 185 middle aged controls. Other plasma lipid levels were measured by routine methods. Results E selectin allele frequencies of A, C were 92 9%,7 1% and 93 3%,6 7% in 198 elderly patients and 187 young patients respectively; 96 6%, 3 4% in elderly control group and 96 8%, 3 2% in middle aged control group respectively. Genotype distribution was in accordance with Hardy Weinberg equilibrium. The distribution of genotype in E selectin A561C was of significant difference between myocardial infarction group and control group( P 0 05). Both myocardial infarction groups showed higher plasma TC, TG and LDL C than controls( P 0 05). Conclusions E selectin A561C polymorphism is associated with myocardial infarction and C allele may be a risk factor for myocardial infarction in Chinese elderlys.