Application of Serum β_2-MG in diagnosing malignant bone tumor

Objective To explore the value of Serum β2-MG in diagnosing malignant bone tumor.Methods Serum β2-MG of 38 patients with malignant bone tumor,12 patients with benign bone tumors and 16 normal healthy adults was examined by radioimmunoassay,and comparative analysis was conducted.Results Three groups of test samples of serum β2-MG levels were(4.17±0.85) mg/L,(1.82±0.37) mg/L and(1.73±0.40) mg/L,which showed that patients with malignant bone tumor of β2-MG levels were significantly higher than that of benign bone tumors and normal adults,and the difference was statistically significant(P0.01).It was also found that the level of β2-MG and malignant bone tumors,clinical staging,and response to treatment had a significant correlation.Conclusion Determination of serum β2-MG can be an aid of diagnosis of malignant bone tumors and assessment of treatment,and one of the serological markers of the condition.