2010•Liaoning Zhongyiyao Daxue xuebaoRequires access
Effect of Yuyang Guanchang Fang on Treatment of Ulcerative Colitis and on IL-4 IL-10 in the Serum
Keli Dong
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Abstract
Objective:To investigate the effects of coloclysis with Yuyang Guanchang Fang on interleukin-4(IL-4) and interleukin-10(IL-10) levels and therapeutic effect in patients of ulcerative colitis. Methods:A total of 60 patients suffered ulcerative colitis were divided randomLy into two groups:treatment group and control group. In the treatment group,30 patients were treated by coloclysis with Yuyang Guanchang Fang(100mL) once a night,and control group were treated by coloclysis with 3g SASP and 5mg dexamethasone dissolved in 100mL warm normal sodium once a night. The clinical curative effect,IL-4 and IL-10 level were observed before and after treatment. Results:After therapy for 4 weeks,Total effective rate of the treatment group (96.67%) was higher than that of control group (73.33%) (P0.05). In the treatment group,IL-4 and IL-10 levels were improved significantly as compared with the control Group (P0.05). Conclusion:Yuyang Guanchang Fang has significant curative effect on treatment of UC,and effectively improved the patients of ulcerative colitis levels of IL-4 and IL-10. The significant effect of Yuyang Guanchang Fang on the patients of ulcerative colitis may be attributed to immune-regulation.