Single and Small dose of mifepristone for Emergency contraception of curative effect observe

Objective:To compare the efficacy, side effects and acceptobility of mifepristone only 10mg or double 10mg for emergency contraception. Methods:220health women, who were after 72 hours of unprotected intercourse coming to my hospital. We used a double-blind randomized. They were all ocated to either group1 or 2 for treatmented one group consists of 162 women anther group consists of 108 women. In group 1 mifepristone 10mg (1 tablet) was taken. In group 2 mifepristone 10mg was taken,After 12 hour mifepristone 10mg was taken again. Follow-up visit was performed on the 7 th day of next expected period of menstruation in order to evaluate the contraceptive efficacy side effects of mifepristone and the changes of menstruation. Result:In either group on women was pregnant and the failure rate of contraception by mifepristone was 0.89% and 0.93% in group 1 and 2, contraceptive rate was 91.09% in group 1 and 91.12% in group 2. There was no statiscical difference between the two groups(P0.05), The side effects were mild, its insidence was less than 10% in eath group. Normal menstraction was 90% and 87% in group 1 and 2, P0.05. Conclusion:It is equally effective and safe to once use little dose and of mifepristone 10mg in emergency contraception.