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2007•Journal of Beijing University of Traditional Chinese MedicineRequires access

Quantitative determination of ginsenoside Rg_1,ginsenoside Rb_1 and notoginsenoside R_1 in effective fraction of Qingnaoxuanqiao Formula by HPLC

Bin Liu

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Abstract

Object To establish a method for the quantitative determination of ginsenoside Rg1,ginsenoside Rb1 and notoginsenoside R1 in the effective fraction of Qingnaoxuanqiao Formula by HPLC.Method The determination was carried out with phenomenex Luna NH2 column(250 mm× 4.6 mm,5 μm).CH3CN-H2O(80∶20) was taken as mobile phase at a flow rate of 1.0 mL/min,and detection wavelength was 203 nm.Result The average recoveries of ginsenoside Rg1,ginsenosideRb1 and notoginsenoside R1 were 101.86%,102.02% and 101.23% respectively,and RSD s of the above three compounds were 1.68%(n=9),1.45%(n=9) and 1.28 %(n=9) respectively.Conclusion The method is simple and accurate,and can be used to determine the content of ginsenoside Rg1,ginsenoside Rb1 and notoginsenoside R1 in the effective fraction of Qingnaoxuanqiao Formula.

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Object To establish a method for the quantitative determination of ginsenoside Rg1,ginsenoside Rb1 and notoginsenoside R1 in the effective fraction of Qingnaoxuanqiao Formula by HPLC.Method The determination was carried out with phenomenex Luna NH2 column(250 mm× 4.6 mm,5 μm).CH3CN-H2O(80∶20) was taken as mobile phase at a flow rate of 1.0 mL/min,and detection wavelength was 203 nm.Result The average recoveries of ginsenoside Rg1,ginsenosideRb1 and notoginsenoside R1 were 101.86%,102.02% and 101.23% respectively,and RSD s of the above three compounds were 1.68%(n=9),1.45%(n=9) and 1.28 %(n=9) respectively.Conclusion The method is simple and accurate,and can be used to determine the content of ginsenoside Rg1,ginsenoside Rb1 and notoginsenoside R1 in the effective fraction of Qingnaoxuanqiao Formula.

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Available abstract

Object To establish a method for the quantitative determination of ginsenoside Rg1,ginsenoside Rb1 and notoginsenoside R1 in the effective fraction of Qingnaoxuanqiao Formula by HPLC.Method The determination was carried out with phenomenex Luna NH2 column(250 mm× 4.6 mm,5 μm).CH3CN-H2O(80∶20) was taken as mobile phase at a flow rate of 1.0 mL/min,and detection wavelength was 203 nm.Result The average recoveries of ginsenoside Rg1,ginsenosideRb1 and notoginsenoside R1 were 101.86%,102.02% and 101.23% respectively,and RSD s of the above three compounds were 1.68%(n=9),1.45%(n=9) and 1.28 %(n=9) respectively.Conclusion The method is simple and accurate,and can be used to determine the content of ginsenoside Rg1,ginsenoside Rb1 and notoginsenoside R1 in the effective fraction of Qingnaoxuanqiao Formula.

Key concepts: Ginsenoside Rg1, Ginsenoside, Chromatography, High-performance liquid chromatography, Chemistry, Fraction (chemistry), Medicine, Ginseng

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Quantitative determination of ginsenoside Rg_1,ginsenoside Rb_1 and notoginsenoside R_1 in effective fraction of Qingnaoxuanqiao Formula by HPLC — Research Paper | ScholarLens