2010•Chinese Journal of Gastroenterology and HepatologyRequires access
Experimental study of acute liver injury in rats treated by bone marrow stem cell transplantation
Juqiang Han
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Abstract
Objective To evaluate the therapeutic effect of acute liver injury in rats by bone marrow stem cell trans-plantation. Methods Acute chemical liver injury rat model was established by 2-acetylamino-fluorene and acute physical liver injury rat model was established by 2 /3 liver resection,respectively. Therapeutic effect of two rat models with acute liver injury cured by transplantations via portal vein or into liver parenchyma was observed. Results In rat models with chemical liver injury,serum albumin was significantly higher in the group transplanted into liver parenchyma than that in the group transplanted via portal vein 3 weeks after transplantation ( P = 0. 03) . In rat models with physical liver injury,serum ALT significantly increased both in the group transplanted into liver parenchyma and the group transplanted via portal vein 48 hours after transplantation. Serum ALT was significantly higher in the group transplanted into liver parenchyma than that in the group transplanted via portal vein. However,AST and serum albumin did not show significant difference ( P 0. 05) . Liver function did not show any abnormality in two groups 3 weeks after transplantation. Conclusion Bone marrow stem cell transplantation contributes to serum albumin in chemical injury rats. Efficacy of introhepatic injection is better than transplantation via portal vein. However,introhepatic injection can result in ALT increase.