Treatment of acute liver injury with rat bone marrow mesenchymal stem cells transplanted in subcapsule of liver in rat

Objective To study the therapeutic effect of rat bone marrow mesenchymal stem cells transplanted under capsule of liver in rat with liver injury. Methods The model rat with acute liver injury was established by intra-abdominal injection of carbon tetrachloride(CCl4). The rat bone marrow stem cells were transplanted into the lacuna of subcapsule(Glisson’s capsule)of liver in rat. The therapeutic effects were evaluated by comparing the levels of albumin(Alb) and aminotransferase(ALT,AST) between the stem cell transplant group and the control group in 3 weeks of transplantation. Results Level of Alb of the transplant group (19.2±2.6) g/L was higher than that of control (12.6±3.5 )g/L significantly (P0.05). Levels of ALT and AST of the transplant group (20.9±5.1),(19.4±3.7) IU/L were significantly lower than that of control (40.7±11.6),(37.9±12.7) IU/L (P0.05). Conclusion The bone marrow mesenchymal stem cells transplanted in subcapsule of liver could improve the liver function in rat with acute liver injury.