2010•Xiandai shengwu yixue jinzhanRequires access
Experimental study on bone marrow mesenchymal stem cell transplantation for chronic liver injury in rats.
Xinghao Lu, Xuelian Pei, Zhiwei Xiao, Lihua Zheng, Xiaoling Mu
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Abstract
Objective:To understand biochemical indicators of liver function and liver histopathological changes by infusion of bone marrow-derived mesenchymal stem cells in rats, to provide experimental basis for clinical applications.Method:The rats were randomly divided into normal group and model group. To Built model group,we inject carbon tetrachloride by intraperitoneal, and then randomly divided into the treatment group, model control group . Stem cell transplantation group tag via portal vein infusion of bone marrow-derived mesenchymal stem cells. Rats were killed after 3 weeks. They then examined the liver function, liver pathology of changes in stem cell transplantation for treatment of liver injury rats. Result:Stem cell transplantation for treatment of 3 weeks later, liver of rats compared with the control group, obviously restored, but did not return to normal levels. Conclusion:Bone marrow-derived mesenchymal stem cells on rats with liver injury has obvious therapeutic effect.