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Multi drug Resistant Genes of Pseudomonas aeruginosa

Ling Qin

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Abstract

OBJECTIVE To study the condition and mechanism of multi drug resistant Pseudomonas aeruginosa.METHODS The genes of beta-lactamase,aminoglycosides modifying enzymes(AMEs) and disinfectant-resistance were determined by polymerase chain reaction(PCR).The sequence of VIM gene was detected.RESULTS The results of PCR indicated that TEM type of beta-lactamase genes,VIM type of metallo-beta-lactamase genes,aac(6′)-Ⅰand,ant(3″)-Ⅰtypes of AMEs genes and qacE△1-sul1 type of disinfectant-resistance genes were positive and oprD2 gene was absent in multi drugresistant P.aeruginosa.The sequence of PCR products of VIM of (metallo)-beta-lactamase genes was analyzed by BLAST(www.ncbi.nlm.nih.gov) and it was VIM-2.(CONCLUSIONS) There are multidrug resistant genes in P.aeruginosa and for this the supporting therapy is(suitable).

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OBJECTIVE To study the condition and mechanism of multi drug resistant Pseudomonas aeruginosa.METHODS The genes of beta-lactamase,aminoglycosides modifying enzymes(AMEs) and disinfectant-resistance were determined by polymerase chain reaction(PCR).The sequence of VIM gene was detected.RESULTS The results of PCR indicated that TEM type of beta-lactamase genes,VIM type of metallo-beta-lactamase genes,aac(6′)-Ⅰand,ant(3″)-Ⅰtypes of AMEs genes and qacE△1-sul1 type of disinfectant-resistance genes were positive and oprD2 gene was absent in multi drugresistant P.aeruginosa.The sequence of PCR products of VIM of (metallo)-beta-lactamase genes was analyzed by BLAST(www.ncbi.nlm.nih.gov) and it was VIM-2.(CONCLUSIONS) There are multidrug resistant genes in P.aeruginosa and for this the supporting therapy is(suitable).

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Available abstract

OBJECTIVE To study the condition and mechanism of multi drug resistant Pseudomonas aeruginosa.METHODS The genes of beta-lactamase,aminoglycosides modifying enzymes(AMEs) and disinfectant-resistance were determined by polymerase chain reaction(PCR).The sequence of VIM gene was detected.RESULTS The results of PCR indicated that TEM type of beta-lactamase genes,VIM type of metallo-beta-lactamase genes,aac(6′)-Ⅰand,ant(3″)-Ⅰtypes of AMEs genes and qacE△1-sul1 type of disinfectant-resistance genes were positive and oprD2 gene was absent in multi drugresistant P.aeruginosa.The sequence of PCR products of VIM of (metallo)-beta-lactamase genes was analyzed by BLAST(www.ncbi.nlm.nih.gov) and it was VIM-2.(CONCLUSIONS) There are multidrug resistant genes in P.aeruginosa and for this the supporting therapy is(suitable).

Key concepts: Pseudomonas aeruginosa, Gene, Microbiology, Biology, Beta-lactamase, Polymerase chain reaction, Drug resistance, Multiple drug resistance

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